New Hope For Diabetic Wound Healing
Diabetes cause several complications, some of which can make wound healing difficult. Incorporate nerve damage and narrowing of bloodstream. Adequate blood flow is required for proper wound healing and both of your conditions adversely customize flow of blood especially to lower limbs and extremities. Diabetic wounds of lower extremities get serious consequences including amputations. A large number of foot ulcers in diabetic patients end up in amputation. Therefore, it is really quite important that diabetic wounds heal as quickly as possible.
Dr. Wonhee Suh of your CHA University Stem Cell Institute, together with colleagues conducted a study using two groups of mice with diabetic wounds. They transplanted one group of mice with human umbilical cord blood-derived endothelial progenitor cells (EPCs). The researchers observed increased wound healing and revascularization in the mice have been given EPC. They discovered that in this group of mice, growth factors and cytokines were produced large quantities at the wound site, which significantly helped in accelerating the healing period.
'The transplantation of EPCs derived from human umbilical blood cells accelerated wound closure in diabetic mice from the primary point,' said Dr. Suh. 'Enhanced re-epithelialization made a large contribution in accelerating wound closure judge. It remains unclear; however, which mechanism plays the dominant role in EPC-mediated tissue regeneration.'
'This experimental study opens the chance the future clinical regarding endothelial progenitor cells derived from human cord blood within the treatment of diabetic wounds in humans' said Prof. Voltarelli, Professor of Clinical Medicine & Clinical Immunology at the University of Sao Paulo, Brazil and section editor for Cell Transplantation. 'Interestingly, it also shows that the culture medium used to grow the cells (conditioned media) has related healing effect as the cells, to make certain that it could possibly be used as a cell-free connected with treatment.'